I had no idea I could get some of these tires so cheap (under $300).  This makes my decision a little easier...
I'm definitely going with a M/T tire at this point.  These tires, in addition to being used for my DD, will also eventually see trails like Rubicon, Dusi-Ershan, and Moab, not to mention the other trails near me in the Sierra Nevada Mountains.  The finalists at this point are:
Nitto Trail Grappler - If I ignore the weight differences, I'd say Nitto is probably my first choice.  It sounds like they have good tread life and I haven't heard a single negative regarding its trail abilities.  They're even quieter on the pavement than most M/Ts.  But that heavy tire is going to kill my MPGs as a DD, right?
Goodyear Wrangler MT/Rs - These are a lot lighter, but I'm reading some people are having balancing issues as well as some soft spots on the sidewalls.  Again, no knocks on trail abilities, but I don't hear many people talk about how they are as a DD.  I can tolerate the balancing issues, but bad sidewalls is not something I want to deal with.  I need some more input from those that run these or have close friends that do.  
As a DD, I have to consider the ride quality on the road.  Goodyear's Load Rating of C or D, depending on the size, should ride better than Nitto's E rated Trail Grappler.  Probably one of the reasons Nitto is so much heavier.  But how do they handle highways and corners?
So my questions:
- Is tread life on these two similar?
- Does one have better ride on the pavement?
- Are the sidewalls on the Goodyear anything I should worry about?
- Is 10 lbs. per tire enough to make a difference?