Where to beginning?!
Downtown have so many bars (dive, high end, Irish, and piano) and clubs range from nice shirt and jeans to vegas style dress code. Same goes for the restaurants there to.
Mission valley has a country bar/club, In cahoots and few other bars/grills.
Little Italy near downtown/airport has plenty of bars and restaurants. Tasty food.
North park has a few bars for tasty beers on tap. Seven grand is whiskey bar stock to the ceiling with bottles! Toranodo's, blind lady ale house(B.L.A.H) just name a few have amazing beers on tap.
Ocean beach, has the best fish tacos at south beach grill. Nice dive bars with cheap drinks on Newport. Watch out for the bums!
Point loma to the light house has great views of downtown with the mountian range in the background!
Pacific beach, bars, bars, bars and restaurants steps from the beach! The Tap Room has the best selection of beers on tap! Rocky's Bar has the best cheeseburger around. Hoboken pizza for late night pizza run. Most of the bars are on garnet ave and mission blvd.
La jolla downtown has la jolla brew house, great site seeing and restaurants with a few clubs at night. Check out the big cross in la jolla, amazing views of all of San Diego. La jolla shore to glider port is cool to check out. Torrey pines golf course right above the beach.
Corando, corando brewing, views of downtown, hotel del is a must.
Pizza port restaurant is located in OB, slogans beach and Carlsbad. Great pizza with amazing micro brews. Talking about micro brews, I think San Diego county has over 30 breweries in a county and not including brewpubs.
Mission beach has Belmont park old ass wooden roller coaster. Sea world.
The Zoo and balboa park is cool to check out with all the museums. There a few casinos in San Diego but at least a 30 minute drive from downtown.
If you need more specifics on things to do let me know.